SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
basic FUNCTION
| protein kinase inhibitor protein that regulates the activity of the Raf/MEK/ERK module |
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inhibits the phosphorylation and activation of MEK by RAF1 |
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may be involved in the function of the presynaptic cholinergic neurons of the central nervous system |
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increases the production of choline acetyltransferase |
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negative modulator of the Raf-MEK-ERK signaling pathway |
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conserved pocket may constitute a novel phosphoamino-acid binding motif and is absolutely required for PEBP1 function |
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novel component of the SNAI1 transcriptional regulatory network important for the progression and metastasis of cancer |
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negatively regulates the MAP kinase (MAPK), G protein-coupled receptor kinase-2, and NF-kappaB signalling cascades |
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modulates cell cycle kinetics and motility |
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physiologic inhibitor of RAF1 kinase and nuclear factor kappaB signaling that represses tumor invasion and metastasis |
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prevents cilia formation and is associated with CEP290-mediated photoreceptor degeneration |
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potentially modulates the localization of a distinct set of proteins required for cilia assembly and maintenance |
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its ability to interact with RAB8A suggests its involvement in the regulation of docking and transport of membrane protein-containing vesicles in photoreceptors |
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regulates growth and differentiation signaling of mitogen-activated protein kinases (MAPK), GRK2 and NF-kappaB pathways each of which regulates cytotrophoblast differentiation and normal placental development |
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novel factor expressed in cytotrophoblast cells where it likely regulates cell migration |
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positive feedback loop between PEBP1 and TBK1 that is essential for type I interferon production in anti-viral innate immunity |