basic FUNCTION
| acting as a negative regulator of mtDNA transcription initiation |
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can mediate the formation of a loop in mitochondrial DNA to promote efficient rRNA synthesis |
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with MTERFD2, and MTERFD3 regulate transcription by acting in the same site in the mtDNA promoter region and thereby mediate fine-tuning of mitochondrial transcription and hence OXPHOS function |
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with MTERFD3 are known to participate in the control of mitochondrial DNA transcription |
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involved in restraining replication fork progression, contributing to genome stability |
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implicated in modulating transcription, replication and protein synthesis |
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novel and unexpected role for MTERF3 in coordinating the crosstalk between transcription and translation for the regulation of mammalian mtDNA gene expression |
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negative regulator of mammalian mitochondrial DNA transcription |