Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CTRB2 contributors: mct - updated : 09-11-2021
HGNC name chymotrypsinogen B2
HGNC id 2522
DNA
TYPE functioning gene
STRUCTURE 3.06 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 870 - 263 - -
6 - - - 166 - -
  • deletion allele of the 584 bp exon 6 structural variant creates a premature stop codon yielding a 166aa protein (148aa after the signal peptide is removed) lacking chain C.
  • structural variant overlapping CTRB2 exon 6 is a functional variant underlying risk for pancreatic cancer at chr16q23.1;this 584 bp genomic deletion results in intracellular accumulation of a nonfunctional CTRB2 protein leading to ER stress
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine     Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • first 18AA comprise a signal peptide that is cleaved off the zymogen upon entry into the ER
  • isoforms Precursor of pancreatic proteolytic enzymes
    HOMOLOGY
    interspecies homolog to murine Ctrb1
    intraspecies paralog to CTRB1
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • peptidase activity
  • playing a key role in the enteroendocrine system (
  • involved in the regulation of the incretin pathway, development of diabetes, and response to DPP-4 inhibitor treatment (
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP/GTP binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to pancreatic cancer
  • to diabetes mellitus
  • Variant & Polymorphism other
  • increased pancreatic cancer risk in carriers of CTRB2 exon 6 deletion alleles, impairing chymotrypsin B2 function and localization
  • CTRB2 deletion variant associated with risk of diabetes mellitus
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS