basic FUNCTION
| probable constituent of the synaptonemal complex during meiosis |
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regulate interactions between homologous chromosomes (homologs) during meiosis in a wide range of eukaryotes |
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meiotic HORMA-domain proteins are required to direct double-strand breaks repair towards homologues |
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involvement of meiotic HORMA-domain proteins in the regulation of homologue interactions is conserved in mammals |
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HORMAD2-dependent recruitment of ATR to unsynapsed chromosome axes constitutes a mechanism for the surveillance of asynapsis |
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SYCP3 and the SYCP2 C terminus, form a compact core around which cohesin complexes, HORMADs, HORMAD1, and HORMAD2 and the N terminus of SYCP2 are arrayed |