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FLASH GENE
Symbol DUSP23 contributors: mct - updated : 19-03-2024
HGNC name dual specificity phosphatase 23
HGNC id 21480
DNA
TYPE functioning gene
STRUCTURE 1.58 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 797 - 150 - 2014 24531476
3 - 699 - 150 - 2014 24531476
3 - 692 - 150 - 2014 24531476
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Reproductivemale systemtestis   
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • a dual-specificity phosphatase catalytic (DSPc) domain
  • residues C-terminal to the TY motif may represent determinants of DUSP23 substrate specificity
  • HOMOLOGY
    Homologene
    FAMILY intracellular, non-receptor VH1-like, atypical dual specificity phosphatases subfamily
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing an important role in the regulation of mitogenic signal transduction and controlling the cell cycle in response to extracellular stimuli
  • protein phosphatase with dual substrate specificity
  • single domain, globular protein, mediating dephosphorylation of phospho-tyrosyl (pTyr) and phospho-seryl/threonyl (pSer/pThr) residues in specific proteins
  • DUSP23 acts likely as a negative regulatory mechanism which ultimately silences the transcription of these epigenetically regulated genes by triggering an increase in the expression of different DNMTs
  • role of DUSP23 in centriole duplication
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of GCM1 and DUSP23 is enhanced by PKA-dependent phosphorylation of GCM1 on Ser269 and Ser275
  • role for DUSP23 in regulating E-cadherin adherens junctions through promoting the dephosphorylation of CTNNB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS