Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DUSP2 contributors: mct - updated : 06-01-2010
HGNC name dual specificity phosphatase 2
HGNC id 3068
DNA
TYPE functioning gene
STRUCTURE 2.27 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
motif repetitive sequence   other
text structure palindromic site in the promoter
MAPPING cloned Y linked Y status provisional
Physical map
LOC389003 2 LOC389003 PROM2 2q11.1 prominin 2 CSEN 2q11.2-q11.3 calsenilin, presenilin binding protein, EF hand transcription factor CGI-105 2p24.3-p11.2 CGI-105 protein LOC129870 2q11.2 similar to autoantigen NOR-90 LOC389004 2 similar to tripartite motif-containing 43 FLJ14082 2q11.2 hypothetical protein FLJ14082 LOC389005 2 similar to RING finger protein 18 (Testis-specific ring-finger protein) TRIM43 2q11 tripartite motif-containing 43 LOC285031 2q11.2 similar to autoantigen NOR-90 LOC129872 2q11.2 similar to Glycerol-3-phosphate acyltransferase, mitochondrial precursor (GPAT) LOC150759 2q11.2 hypothetical protein LOC150759 LOC389006 2 similar to KIAA1641 protein LOC389007 2 similar to hypothetical protein LOC150763 2q11.2 hypothetical protein LOC150763 ADRA2B 2p13-q13 adrenergic, alpha-2B-, receptor LOC200515 2q11.2 similar to hypothetical protein 7420700F21 DUSP2 2q11 dual specificity phosphatase 2 STARD7 2q11.1 START domain containing 7 FLJ20507 2q11.2 hypothetical protein FLJ20507 CIAO1 2q11.2 hypothetical protein FLJ20507 U5-200KD 2q11.1 hypothetical protein FLJ20507 KIAA1754L 2q11.2 KIAA1754-like BRRN1 2q11.2 barren homolog (Drosophila) LOC93082 2q11.2 hypothetical protein BC012317 MRF-1 FLJ10081 2p12-p11.2 hypothetical protein FLJ10081 LOC391408 2 similar to myoferlin isoform b; fer-1-like 3 LOC90342 2q11.2 similar to fer-1 like protein 3 LMAN2L 2q11.1 lectin, mannose-binding 2-like CNNM4 2p12-p11.2 cyclin M4 LOC130643 2q11.2 hypothetical LOC130643 CNNM3 2p12-p11.2 cyclin M3 DARP MGC41816 2q11.2 hypothetical protein MGC41816
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1708 34.3 314 - 2007 17471234
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cell lineage hematopoietic cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N terminal CH2 domains
  • an extended active site sequence motif conserved in dual specificity phosphatases
  • HOMOLOGY
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class dual specificity subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • negative regulator of mitogen activated protein (MAP) kinase family
  • playing a role necessary and sufficient for TP53 -induced apoptosis and growth suppression
  • inducible, nuclear-specific, dual-specificity mitogen-activated protein (MAP) kinase phosphatase that is a transcription target of TP53 in signaling apoptosis and growth suppression
  • involved in ERK2 dephosphorylation, requiring association of its N-terminal domain with ERK2 that results in catalytic activation of the phosphatase
  • having a crucial role in E2F1-directed apoptosis
  • involved in stimulus-specific, and phosphatase-specific mechanism of MAPK1 regulation in the nucleus
  • with DUSP1, and DUSP10 are crucial players in the regulation of immune responses, but other members of the family, like the ERK-specific DUSP6, play a major role in development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inactivating ERK1, ERK2
  • direct transcription target of E2F1 in signaling apoptosis
  • cell & other
    REGULATION
    activated by TP53 during apoptosis
    induced by in response to serum deprivation and oxidative stress
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS