protein
| interacting with ADAM17 (ALCAM shedding by the metalloprotease ADAM17 is involved in motility of ovarian carcinoma cells)(Rosso 2007) |
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ALCAM synergizes with NGF to induce neuronal differentiation, raising the possibility that it functions not only as an adhesion molecule but also in the modulation of growth factor signaling in the nervous system |
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ALCAM directly associates with the tetraspanin CD9 on the leukocyte surface in protein complexes that also include the metalloproteinase ADAM17/TACE |
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contribute to DC-T-cell adhesion, stabilize DC-T-cell contacts and form a mechanical link between CD6 and the actin cortex to strengthen cell adhesion at the immunological synapse |
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ALCAM stably interacts with actin by binding to SDCBP and EZR, and interaction with the ligand CD6 further enhances these multiple interactions |
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AKT1 is an inter-mediator between the upstream regulator, ALCAM, and downstream effector, FOXO1, in liver cancer cells |
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interaction of LGALS1 and LGALS3 with CD6 and CD166/ALCAM might modulate some relevant aspects of T cell physiology |
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interaction between CD6 and ALCAM regulating T-cell activation |
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LGALS8 interacts with ALCAM at the surface of breast cancer cells through glycosylation-dependent mechanisms |
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PRMT1 is overexpressed in human melanoma, and may regulate tumor growth and metastasis via targeting ALCAM |
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CD6 facilitates adhesion between T cells and antigen-presenting cells through its interaction with ALCAM, and physically associates with the T cell receptor (TCR) at the center of the immunological synapse |
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SH3GL3 associates with ALCAM-containing early endocytic carriers and physically interacts with the cargo |