basic FUNCTION
| having ubiquitin-protein ligase activity |
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E3 ubiquitin ligase, accumulated in DSB repair foci through recognition of RNF168-catalyzed ubiquitylation products by its motif interacting with ubiquitin domain |
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dispensable for chromatin ubiquitylation and ubiquitin-dependent accumulation of repair factors at DSB sites |
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is a negative regulator of the DNA damage signaling cascade |
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is a component in DNA damage signal transduction and adds to the complexity of regulatory ubiquitylation in genome stability maintenance |