basic FUNCTION
| acting as a phospholipase receptor |
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presence on neutrophils and having role in elastase release and adhesion (Silliman 2002) |
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regulates a variety of biological responses elicited by secretory phospholipase A2s (sPLA2s) (Hanasaki 2004) |
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potential new tumour suppressor gene crucial in the induction of cellular senescence through the activation of the TP53 pathway (Augert 2009) |
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genetically modifying the expression has an important impact on the senescence of primary cells (Augert 2009) |
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could regulate senescence by controlling the production of cytokines, as is able to regulate cytokines (cytokines are involved in senescence outcome) and is a new crucial regulator of senescence in human primary cells (Augert 2009) |