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FLASH GENE
Symbol RASL11A contributors: mct/npt - updated : 24-10-2009
HGNC name RAS-like, family 11, member A
HGNC id 23802
DNA
TYPE functioning gene
STRUCTURE 3.36 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1543 - 242 - Louro (2004)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
 stomach   moderately
Reproductivefemale systembreastmammary gland moderately
 male systemprostate  predominantly
Respiratorylung   highly
Urinarykidney   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • small GTPase protein family
  • Ras subfamily
  • CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleolus
    text
  • plasma membrane-associated
  • nucleolar protein associated with ribosomal DNA (rDNA) and with the RNA polymerase I (RPI)-specific transcription factor UBTF (Pistoni 2010)
  • basic FUNCTION
  • regulating cellular responses
  • involved in epithelial cell polarization processes
  • causing the formation of thin, actin-rich surface projections called filopodia
  • may be acting in concert with UBTF to facilitate initiation and/or elongation by RNA polymerase I in response to specific upstream stimuli (Pistoni 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text protein transport
    PATHWAY
    metabolism
    signaling signal transduction
    small GTPase mediated signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein interacting with UBTF (co-localizes with UBTF not only at nucleoli in interphase, but also on chromosomes in mitotic cells)(Pistoni 2010)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS