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FLASH GENE
Symbol DEFB109P1 contributors: shn - updated : 04-04-2011
HGNC name defensin, beta 109, pseudogene 1
HGNC id 18090
DNA
TYPE pseudogene
SPECIAL FEATURE
text translation start site (ATG) in the upstream region is unknown
STRUCTURE 7.08 kb     1 Exon(s)
MAPPING cloned N linked N status provisional
Map pter - D8S1695 - D8S1759 - DEFB109P1 - D8S552 - D8S1106 - qter
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 189 - - ocular surface epithelium, highly concentrated in superficial layers of corneal epithelium, conjunctiva, and limbus - 20375350
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiens
Digestiveintestinelarge intestinecolon lowly Homo sapiens
 intestinesmall intestine  moderately Homo sapiens
 liver   highly Homo sapiens
Endocrinepancreas   highly Homo sapiens
Lymphoid/Immunespleen   moderately Homo sapiens
 thymus   lowly Homo sapiens
Nervousbrain   highly Homo sapiens
Reproductivefemale systemovary  highly Homo sapiens
 female systemplacenta  moderately Homo sapiens
 male systemprostate  lowly Homo sapiens
 male systemtestis  highly Homo sapiens
Respiratorylung   highly Homo sapiens
Urinarykidney   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal lowly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a consensus six-cysteine motif
  • HOMOLOGY
    Homologene
    FAMILY human beta-defensins
    CATEGORY
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • constitutively present in gingival keratinocytes and to be downregulated in response to Candida albicans
  • may have a role in ocular surface epithelium defense against invading pathogens
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text host defense against microbial infection
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other HBD9 expression is modulated in response to the activation of TLRs in corneal epithelial cells (
    HBD9 Expression is modulated by NOD2 in corneal epithelial cells (
    regulated by IL-1beta in corneal epithelial cells (
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS