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FLASH GENE
Symbol SLC25A37 contributors: mct/npt - updated : 21-03-2019
HGNC name solute carrier family 25, member 37
HGNC id 29786
DNA
TYPE functioning gene
STRUCTURE 43.70 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1865 - 338 - Hu (2000)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunelymph node    
 spleen    
Nervousbrainforebraincerebral cortex highly
Olfactory (smell)olfactory bulb   highly
Reproductivefemale systemovary  highly
Respiratorylung    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmature hematopoietic
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text hematopoietic tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • interaction domain with ABCB10 localized to the N terminus between the first 26 to 50 AAs (Chen 2009)
  • three solcar repeats
  • HOMOLOGY
    intraspecies homolog to SLC25A8
    Homologene
    FAMILY
  • mitochondrial carrier family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION
  • may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations)
  • mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells,
  • thereby playing an essential role in heme biosynthesis
  • functions as the principal mitochondrial iron importer essential for haem biosynthesis in vertebrate erythroblasts (Shaw 2006)
  • essential for heme and Fe/S cluster synthesis in erythroblasts and is required for primitive and definitive erythropoiesis (Chen 2009)
  • functions as an essential iron importer for the synthesis of mitochondrial heme and iron–sulfur clusters in erythroblasts (Chen 2009)
  • in erythroid cells, ferrous iron is imported into the mitochondrion by SLC25A37
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • FECH forms an oligomeric complex with SLC25A37 and ABCB10 to synergistically integrate mitochondrial iron importation and use for heme biosynthesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically interacts with ABCB10 (enhance its protein stability and, as a consequence, increase iron import into the mitochondria) (Chen 2009)
  • SLC25A37 interacts with ABCB10 to enhance mitochondrial iron importation
  • is a mitochondrial transporter of Fe used for heme formation by FECH and for 2Fe2S cluster synthesis, which is critical to FECH activity/stability
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS