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FLASH GENE
Symbol MTPAP contributors: mct - updated : 02-12-2010
HGNC name mitochondrial poly(A) polymerase
HGNC id 25532
DNA
TYPE functioning gene
STRUCTURE 124.78 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 56.20 66.2 582 - 2004 15547249
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 intestinesmall intestine  highly
Reproductivefemale systembreastmammary gland moderately
 female systemovary  moderately
Respiratoryrespiratory tractlarynx  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Papd1
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION
  • nuclear-encoded mitochondrial poly(A) RNA polymerase, implicated in polyadenylation of mRNA, and essential for maintaining mitochondrial gene expression
  • MTPAP, PAPD4, PAPD5, ZCCHC6, ZCCHC11, and TUT1, were found to govern 3prime nucleotide addition to miRNAs in a miRNA-specific manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPAX4
    Susceptibility
    Variant & Polymorphism
    Candidate gene potential candidate gene for the extreme obesity
    Marker
    Therapy target
    ANIMAL & CELL MODELS