Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FAM102A contributors: mct - updated : 23-05-2018
HGNC name family with sequence similarity 102, member A
HGNC id 31419
DNA
TYPE functioning gene
STRUCTURE 39.95 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 4161 - 384 - 2013 23478294
8 - 3643 - 242 - 2013 23478294
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
Lymphoid/Immunelymph node   highly
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies paralog to SKAP1
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
text
  • expression of EEIG1 protein occurs predominantly in the cytoplasm
  • basic FUNCTION
  • playing a role in estrogen action
  • positively regulates TNFSF11-induced osteoclast formation, likely due to its ability to facilitate TNFSF11-stimulated PLCG2 phosphorylation and NFATC1 induction
  • is a novel TNFRSF11A signaling component that is required for osteoclastogenesis
  • FAM102A plays a critical role in TNFRSF11A-induced osteoclast differentiation, and its role may be closely related to the induction of NFATC1
  • important role of EEIG1 in osteoclast differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FAM102A is a novel TNFRSF11A signaling component controlling TNFRSF11A-mediated osteoclast formation
  • TNFRSF11A-FAM102A signaling complex is necessary for PLCG2 phosphorylation that is required for the induction of NFATC1
  • FAM102A is a new interactor of SKAP2 (FAM102A adaptor interacts with the SH3 domain of SKAP2 by a binding motif containing Pro149)
  • FAM102A protein interacts with SKAP1 protein, a paralog of SKAP2 mainly expressed in hematopoietic cells
  • cell & other
    REGULATION
    induced by by 17 beta-estradiol
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularbone 
    might represent a new therapeutic strategy for the treatment of pathological bone resorption
    ANIMAL & CELL MODELS