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FLASH GENE
Symbol ZDHHC20 contributors: mct - updated : 28-12-2021
HGNC name zinc finger, DHHC domain containing 20
HGNC id 20749
DNA
TYPE functioning gene
STRUCTURE 86.78 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 5250 - 292 - 2020 31858978
12 - 5274 - 354 - 2020 31858978
13 - 5355 - 365 - 2020 31858978
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemplacenta   
 male systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
intracellular,nuclear envelope
basic FUNCTION
  • ZDHHC17, ZDHHC18, ZDHHC20, and ZDHHC21 exhibited weak or moderate activities
  • DHHC20 induces a drastic deformation in the membrane, particularly on the cytoplasmic side, where autoacylation occurs
  • palmitoyltransferase DHHC20 palmitoylates EGFR on the C-terminal domain and plays a critical role in signal regulation during oncogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZDHHC20 uniquely increased IFITM3 antiviral activity when both proteins were overexpressed
  • during SARS-CoV-2 infection, spike becomes lipid modified, through the sequential action of the S-acyltransferases ZDHHC20 and ZDHHC9
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    promoted the palmitoylation of SARS-CoV-2 S, establishing role of S palmitoylation in syncytia formation and virus entry
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS