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FLASH GENE
Symbol B4GALNT3 contributors: SGE - updated : 27-07-2010
HGNC name beta-1,4-N-acetyl-galactosaminyl transferase 3
HGNC id 24137
DNA
TYPE functioning gene
STRUCTURE 101.52 kb     20 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 3438 - 998 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 stomach   highly
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal transmembrane domain
  • four potential N-glycosylation sites
  • a DXH sequence thought to participate in divalent cation binding
  • a C-terminal WGGED motif (Sato 2003)
  • HOMOLOGY
    interspecies homolog to murine B4galnt3 (84.7pc)
    homolog to rattus B4galnt3 (83.5pc)
    Homologene
    FAMILY
  • chondroitin N- acetylgalactosaminyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • could transfer GalNAc residues, producing N, N'-diacetylgalactosediamine structures at least in N-glycans and probably in both N- and O-glycans
  • up-regulation of B4GALNT3 may contribute to the malignant behavior of colon cancer cells (Huang 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in colon cancer cell line, enhancing cell-extracellular matrix adhesion, migration, anchorage-independent growth and invasion (Huang 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS