SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,nucleus,nucleoplasm
|
| intracellular,nucleus,chromatin/chromosome,telomere
|
| intracellular,nucleus,nucleolus
|
text
| localizes mainly in the nucleolus, which has a known role in maintaining nuclear shape |
|
is not only predominantly distributed in the nucleolus in interphase, but is also concentrated in the mitotic midbody during telophase |
basic FUNCTION
| influences the activity of histone acetylation and could up-regulate telomerase activity through transactivation of TERT promoter |
|
may play an important role in cell division through facilitating reformation of the nucleolus and midbody in the late phase of cell mitosis, and stabilization of microtubules |
|
lysine acetyltransferase that targets microtubules and histones and plays an important role in cell division |
|
is an ATP-dependent RNA acetyltransferase responsible for formation of N(4)-acetylcytidine (ac(4)C) at position 1842 in the terminal helix of mammalian 18 S rRNA |
|
RNA cytosine acetyltransferases with, surprisingly, specificity toward both 18S rRNA and tRNAs |
|
effects of NAT10 on laminopathic cells are due to reduced ribosome biogenesis or function |
|
NAT10 plays a critical role in TP53 activation via acetylating TP53 and counteracting MDM2 action, providing a novel pathway by which nucleolar protein activates TP53 as a cellular stress sensor |
|
plays a role in the transition between rRNA biogenesis and autophagy |
|
participates in different maturation events, such as acetylation and processing of 18S rRNA, and assembly of the 40S ribosomal subunit |
|
role of human NAT10 in Hutchinson-Gilford progeria syndrome |