basic FUNCTION
| multifunctional sorting protein indirectly controlling juxtaposition of the organelles through BCAP31-dependent fission and perinuclear clustering of mitochondria |
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cytosolic sorting protein, integrating ER-mitochondria communication, ER homeostasis, and apoptosis and controling the apposition of mitochondria with the ER |
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through its functions, is an important regulator of apoptosis onset |
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regulates GGA3 binding to cargo |
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is required for localizing polycystin-2 to the ER |
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TRAIL effector required for killing virally infected hepatocytes |
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endocytic sorting pathway involved in HIV-1 immunoevasion |
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ER trafficking machinery is pirated by KSHV |
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in the nucleus, PACS2 controls the SIRT1-TP53 axis to promote cell cycle arrest following DNA damage response by directly inhibiting SIRT1-dependent deacetylation of TP53, and in the cytoplasm, regulates endoplasmic reticulum (ER) homeostasis, ER-mitochondria communication, autophagy, and endosomal trafficking of ion channels, receptors, and enzymes |
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PACS2 is an in vivo mediator of the SIRT1-TP53-CDKN1A axis that modulates the DNA damage response |
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role for PACS2 selectively in NFKB1 activation in response to DNA damage |
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multifunctional sorting protein involved in nuclear gene expression and pathway traffic regulation |