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FLASH GENE
Symbol APOOL contributors: mct - updated : 21-11-2017
HGNC name apolipoprotein O-like
HGNC id 24009
DNA
TYPE functioning gene
STRUCTURE 89.47 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 6479 29 268 - 2015 25764979
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel    
Digestivemouthtongue   
Lymphoid/Immunelymph node    
Urinarybladder    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text stem cell
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine 9430083G14Rik
Homologene
FAMILY
  • apolipoprotein O family
  • FAM121 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • is a mitochondrial membrane protein facing the intermembrane space
  • is a cardiolipin-binding component of the IMMT/MINOS protein complex determining cristae morphology in mammalian mitochondria
  • APOO and APOOL, regulate their levels in an antagonistic manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CHCHD6, APOOL and APOO appear to be periphery subunits of the MICOS complex, because their depletion does not affect cristae morphology or stability of other components
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind the mitochondrial phospholipid cardiolipin (CL) and interact physically with this complex
  • APOOL physically interacts with several subunits of the MINOS complex, namely IMMT, MINOS1, and SAMM50
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    led to fragmentation of mitochondria, a reduced basal oxygen consumption rate, and altered cristae morphology
    constitutional     --low  
    impaired mitochondrial respiration and caused major alterations in cristae morphology
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS