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FLASH GENE
Symbol SLC7A14 contributors: mct - updated : 01-12-2015
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
HGNC id 29326
DNA
TYPE functioning gene
STRUCTURE 126.52 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 10133 - 771 - 2006 17417706
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
Nervousbrainhindbraincerebellum highly Homo sapiens
 spinal cord   highly Homo sapiens
Skin/Tegumentskin     Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
not specificfibroblast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 14 transmembrane domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    text localizes almost exclusively to lysosomes
    basic FUNCTION
  • amino acid-polyamine transporter activity
  • lysosomal localized protein with a functional domain that mediates arginine transport
  • may mediate cationic amino acid transport across lysosomal membranes
  • may represent a system c transporter
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RP68
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS