acting as a regulator of Rho guanosine triphosphatases
-
splicing
3106
15
139
. restricted to prostate and liver
. up-regulated by androgens in LNCaP cells
. Up-regulation sensitive to actinomycin D
. expression controlled by an alternate androgen-responsive promoter of the SGEF gene
PMID: 15133129
also called CSGEF
1 SH3 domain
N-terminally truncated form of SGEF designated C-terminal SGEF (CSGEF)
functioning as an androgen-induced regulator of Rho guanosine triphosphatase activity in epithelial cells of the human prostate
EXPRESSION
Type
restricted
expressed in
(based on citations)
organ(s)
System
Organ level 1
Organ level 2
Organ level 3
Organ level 4
Level
Pubmed
Species
Stage
Rna symbol
Digestive
liver
highly
Nervous
brain
moderately
Reproductive
male system
prostate
highly
male system
testis
highly
cells
System
Cell
Pubmed
Species
Stage
Rna symbol
Digestive
hepatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
proline-rich N-terminus required to generate dorsal, but not lateral, membrane ruffles
a functional SH3 domain required to colocalize with filamentous actin at sites of membrane protrusion