Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ZCCHC8

contributors: mct - updated : 21-08-2013

HGNC name	zinc finger, CCHC domain containing 8
HGNC id	25265

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	29.40 kb     14 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017612 14 - 4183 NP_060082 - 707 - 2005 16263084

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine       Endocrine thyroid       highly Hearing/Equilibrium ear inner cochlea   highly Lymphoid/Immune lymph node         Reproductive male system testis     highly Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

CCHC-type zinc finger

HOMOLOGY

interspecies

ortholog to murine Zcchc8

Homologene

FAMILY

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	ZCCHC8 and RBM7 are excluded from nucleoli

basic FUNCTION

GSK3 substrate with a role in RNA metabolism

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

part of the trimeric Nuclear Exosome Targeting (NEXT) complex, containing SKIV2L2, the Zn-knuckle protein ZCCHC8, and the putative RNA binding protein RBM7

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

interacts with proteins involved in RNA processing/degradation (directly phosphorylated by GSK3)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS