Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol E2F7 contributors: mct - updated : 15-03-2022
HGNC name E2F transcription factor 7
HGNC id 23820
DNA
TYPE functioning gene
STRUCTURE 44.33 kb     13 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 5725 - 911 - 2004 15133492
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuteruscervix  
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two DNA-binding domains (DBDs)
  • HOMOLOGY
    Homologene
    FAMILY E2F family of transcription factors
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text
  • localises to the perinucleolar region (PMID;
  • basic FUNCTION
  • playing an essential role in the regulation of cell cycle progression
  • regulating the expression of genes involved in cell cycle, DNA replication, DNA repair, and mitosis
  • E2F7 and E2F8 contain two DNA-binding domains (DBDs) and act as repressors
  • synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer
  • E2F7 is a key player in DNA damage-dependent transcriptional regulation of cell-cycle genes
  • is an atypical E2F family member that acts as a transcriptional repressor of E2F target genes, and thereby contributes to cell cycle arrest
  • E2F7 and E2F8 act as tumor suppressors via transcriptional repression of genes involved in S-phase entry and progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binds to the E2F DNA binding consensus site independently of DP co-factors
    RNA
    small molecule
    protein
  • unique repressor of a subset of E2F target genes whose products are required for cell cycle progression
  • TP53-dependent transcriptional up-regulation of its target, E2F7, leads to repression of relevant gene expression
  • E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1A
  • E2F7 restricts homologous recombination through the transcriptional repression of RAD51
  • CCNF-dependent degradation of E2F7 is critical for DNA repair and G2-phase progression
  • mechanistically, SAPCD2 could directly bind to cytoplasmic E2F7 but not E2F1, alter the subcellular distribution of E2F7 and regulate E2F activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    predicts poor prognosis in human patients with gliomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might act as an independent prognostic factor of gliomas
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    might constitute a potential therapeutic target for gliomas
    ANIMAL & CELL MODELS