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FLASH GENE
Symbol POLR3G contributors: mct/npt - updated : 31-01-2022
HGNC name polymerase (RNA) III (DNA directed) polypeptide G (32kD)
HGNC id 30075
DNA
TYPE functioning gene
STRUCTURE 40.63 kb     8 Exon(s)
regulatory sequence Promoter
text structure POLR3G and POLR3GL promoters are differentially regulated, probably at least in part through exclusive binding of MYC to the POLR3G TSS
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 3285 - 223 - 2017 28494942
8 - 3523 - 223 - 2017 28494942
8 - 3287 - 222 - 2017 28494942
8 - 3280 - 223 - 2017 28494942
8 - 3277 - 222 - 2017 28494942
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   predominantly
Lymphoid/Immunelymph node   highly
Reproductivefemale systembreastmammary gland highly
 female systemovary  moderately
 female systemuterus  moderately
 male systemprostate  moderately
Skin/Tegumentskin   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a core-interacting domain of POLR3G sufficient for the interaction with POLR3C
  • mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Polr3g
    intraspecies paralog to POLR3GL
    Homologene
    FAMILY
  • eukaryotic RPC7 RNA polymerase subunit family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • expressed at high levels in human pluripotent stem cells (hPSCs)
  • basic FUNCTION
  • may be involved either in the recruitment and stablization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation
  • nucleotidyltransferase
  • the primary function of POLR3G is in the maintenance rather than repression of transcription
  • may be required for maintenance of pluripotency, perhaps through expression of specific pol III products
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the RNA polymerase III consisting of about 15 different subunits
  • forming a subcomplex with POLR3C and POLR3F
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • POLR3G is a molecular bridge in between POLR3C domains
  • among the direct targets of POLR3G, POLG is potentially important in sustaining stem cell status in a POLR3G-dependent manner
  • POLR3G binds to telomerase reverse transcriptase (TERT), a protein that enhances the proliferative capacity of many stem and cancer cell types
  • POLR3G and POLR3GL containing Pol III complexes bind the same target genes and assume the same functions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    selectively triggers proliferative arrest and differentiation of prostate cancer cells
    tumoral     --over  
    in transitional bladder cell carcinoma, and correlated with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • can potentially be used as a prognostic marker for transitional bladder cell carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    targeting POLR3G might trigger differentiation, thereby reducing tumourigenicity
    ANIMAL & CELL MODELS
  • POLR3G knockout mice die at a very early embryonic stage