Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EDC4 contributors: mct - updated : 07-02-2014
HGNC name enhancer of mRNA decapping 4
HGNC id 17157
DNA
TYPE functioning gene
STRUCTURE 11.00 kb     29 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
29 - 4739 152 1401 - 1997 9067524
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  predominantly
Lymphoid/Immunethymus   highly
Reproductivefemale systemplacenta  moderately
 female systemuterus  lowly
 male systemtestis  lowly
Respiratoryrespiratory tractlarynx  moderately
Skin/Tegumentskin   moderately
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • an N-terminal WD40-repeat domain connected by a low-complexity region to a conserved C-terminal domain
  • a central serine-rich region
  • a putative hydrophilic nuclear localization sequence (NLS) near its C terminus, and the C-terminal domain interacts with DCP2 and mediates EDC4 oligomerization and P-body localization
  • HOMOLOGY
    Homologene
    FAMILY
  • Ge-1 protein family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • may be a target of human autoantibodies
  • bridging the interaction between DCP1 and DCP2
  • might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • COASY/EDC4 complex formation is regulated by growth factors and is affected by cellular stresses
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PATL1 interacting with DCP2/DCP1A, LSM1/LSM4, EDC4, and EDC3
  • interacts with and regulates the dephospho-CoA kinase activity of CoA synthase
  • XRN1 directly interacts with EDC4 and ACE
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS