SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,nucleus
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basic FUNCTION
| catalyzing the phosphorylation of phosphatidylinositol-4- phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol-4,5-biphosphate |
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selectively regulating the sorting and traffic of peripheral endosomes containing lysosomally directed fluid phase cargo by controlling the morphogenesis and function of multivesicular bodies |
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important in multivesicular body/late endocytic function |
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with the phosphatase FIG4, constitute a single multiprotein complex organized by the PIKFYVE regulator VAC14 and its ability to homodimerize |
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plays an important role in membrane trafficking, including TGN to endosome retrograde sorting and in insulin-stimulated translocation of the SLC2A4 glucose transporter from intracellular storage vesicles to the plasma membrane |
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potential role for PIKFYVE in NPM-ALK-mediated invasion |
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direct function of MTM1 enzymatic activity in SR remodeling and a key role for PIKFYVE in promoting sarcoplasmic reticulum (SR) membrane curvature in skeletal muscle |
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lipid kinase phosphorylating PtdIns(3)P into PtdIns(3,5)P2 whereas the FIG4 lipid phosphatase antagonizes this reaction |
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implicated in insulin-regulated SLC2A4 translocation/glucose entry in 3T3L1 adipocytes |
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essential for systemic glucose homeostasis and insulin-regulated glucose uptake/GLUT4 translocation in skeletal muscle |
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VAC14 acts in a complex with the lipid kinase PIKFYVE and its counteracting phosphatase FIG4, regulating the interconversion of phosphatidylinositol-3-phosphate to phosphatidylinositol-3,5-bisphosphate |