basic FUNCTION
| excise uracil from DNA and acting as a uracil DNA N-glycosylase |
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removing uracil from single- and double-stranded DNA in nuclear chromatin, thus contributing to base excision repair |
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coordinate the initial steps of base excision repair by distinct mechanisms and may be more important in repair of deaminated cytosine (U:G) in non-replicating chromatin |
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showed broader substrate specificity than UNG2 |
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acting as a broad specificity backup |
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remove some oxidized pyrimidines, suggesting a role in the repair of DNA oxidation damage |
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in the presence of Mg2+ and monovalent salts, SMUG1 is essentially double strand-specific |
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base excision repair enzyme that removes uracil and oxidised pyrimidines from DNA |
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UNG and SMUG1 are the two uracil-DNA glycosylases (UDGs) most likely to combat the genomic incorporation of uracil and 5-Fluorouracil (5-FU) during replication |
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has a role in the resumption of replication following 5-FU treatment |