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FLASH GENE
Symbol SSR3 contributors: mct - updated : 02-05-2017
HGNC name signal sequence receptor, gamma (translocon-associated protein gamma)
HGNC id 11325
DNA
TYPE functioning gene
STRUCTURE 15.65 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 4331 - 185 - 2013 23660295
5 - 4370 - 198 - 2013 23660295
5 - 4196 - 133 - 2013 23660295
5 - 4220 - 133 - 2013 23660295
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveintestinesmall intestine  highly
 liver   moderately
Lymphoid/Immunespleen   moderately
Nervousbrain   moderately
Reproductivefemale systemuterus  moderately
 male systemprostate  highly
Respiratoryrespiratory tractlarynx  moderately
Skin/Tegumentskin   moderately
Urinarybladder   highly
 kidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four predicted transmembrane domains
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies ortholog to murine Ssr3
    Homologene
    FAMILY
    CATEGORY regulatory , receptor membrane
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    text
  • integral to endoplasmic reticulum membrane
  • translocon complex
  • basic FUNCTION
  • binding calcium to the ER membrane
  • regulating the retention of ER resident proteins
  • appears to be likely required for vascular network formation in placental development
  • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS
    text
  • cotranslational protein-membrane targeting
  • protein translocation across the ER membrane
  • PATHWAY
    metabolism
    signaling
    a component
  • heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • interaction between NR4A1 and SSR3 (ligand-binding domain of NR4A1 was required for SSR3 binding, and the C terminus of SSR3 was responsible for its interaction with NR4A1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in esophageal squamous cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS