may function as a transcription factor during development
regulates formation of the epidermal leading edge during eyelid closure
GRHL3 and LMO4 play coordinate roles in epidermal migration
may play important roles in mammalian development
cooperative roles of the GRHL genes in epidermal development
required for endothelial cell migration
nitric oxide dependent migration is completely dependent on GRHL3 expression, in breast cancer cells
IRF6 and GRHL3 are essential for the presence of a functional oral periderm and that failure of this process contributes to VWS
is essential during epidermal development, is dispensable for adult skin homeostasis, but required for barrier repair after adult epidermal injury
contributions of GRHL3, SSTR2 and SSTR4 receptors in olfactory processing
CELLULAR PROCESS
nucleotide, transcription
PHYSIOLOGICAL PROCESS
development
PATHWAY
metabolism
signaling
TFAP2A-IRF6-GRHL3 genetic pathway is shared by two embryologically distinct morphogenetic events that previously were considered independent during mammalian development
a component
homodimers and heterodimers with GRHL1 and GRHL2
INTERACTION
DNA
RNA
small molecule
protein
LMO4 serves as a functional partner of GRHL3
GRHL3/GET1 recruits the ubiquitously expressed Trithorax complex to a subset of differentiation genes
major role for GRHL3 in the induction of migration and invasion by the downregulation of CDH1 in cancer cells