Isoforms B, C, and D have an identical N terminus that is encoded by exon 3, and contain a predicted mitochondrial localization signal also encoded by exon 3
6
-
4242
-
192
mitochondrial
2004
15249228
isoform a
N-terminus has a predicted endoplasmic reticulum localization signal (AAs 1–31), whereas the remaining peptide encodes a methionine sulfoxide reductase (Msr domain) that catalyzes the reduction of oxidized methionine AAs and thus repairs oxidatively damaged proteins
8
-
4598
-
185
-
2004
15249228
isoform C
Isoforms B, C, and D have an identical N terminus that is encoded by exon 3, and contain a predicted mitochondrial localization signal also encoded by exon 3
7
-
4296
-
185
-
2004
15249228
isoform D
Isoforms B, C, and D have an identical N terminus that is encoded by exon 3, and contain a predicted mitochondrial localization signal also encoded by exon 3
localized in the endoplasmic reticulum and mitochondria
basic FUNCTION
catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine
with SEPX1, and MSRB2, required for lens cell viability, and their silencing in lens cells results in increased oxidative-stress-induced cell death
important as antioxidant/repair systems for neutrophils, cells with enormous capacity for the generation of reactive oxidants and hence, susceptible to oxidative damage
repair enzymes that protect proteins from oxidative stress by catalyzing stereospecific reduction of oxidized methionine residues
MSRB3-catalyzed reduction of methionine sulfoxides to methionine is essential for hearing
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
metal binding,
binding one Zn2+ per subunit
protein
interaction with selenocompounds which can serve as oxidoreductants