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FLASH GENE
Symbol CDADC1 contributors: mct/npt - updated : 12/11/2008
HGNC name cytidine and dCMP deaminase domain containing 1
HGNC id 20299
DNA
TYPE functioning gene
STRUCTURE 45.52 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3364 58.3 514 - Liu (2006)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Reproductivemale systemtestis  highly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two dCMP_cyt_deam domains, indicating a potential functional role for zinc ion binding
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Cdadc1
    Homologene
    FAMILY
  • cytidine and deoxycytidylate deaminase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • mainly cytoplasmic
  • small amount found in the nucleus
  • basic FUNCTION
  • DNA deaminase (cytidine deaminase)
  • mediating a form of innate resistance to retroviral infections by triggering G-to-A hypermutation in the newly synthetized viral DNA
  • may play an important role in testicular development and spermatogenesis and may be an important factor governing male infertility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS