SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| intracellular,nucleus
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| intracellular,nuclear envelope
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text
| perinuclear region of cytoplasm |
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colocalizes specifically with the microtubules |
basic FUNCTION
| promoting in vitro the polymerization of tubulin into double-walled tubules and polymorphic aggregates or bundled stabilized microtubules blocks |
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inhibiting mitotic spindle assembly and nuclear enveloppe breakdown, when overexpressed, apparently without affecting other cellular events |
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associated with a basic function of cilia |
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multiple effector of the microtubule organization, having microtubule bundling activity able to protect the microtubules from depolymerization |
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influences the microtubule dynamics by decreasing the growth velocity of the microtubule plus ends and also affects cell motility |
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may be controling the differentiation of oligodendrocytes via microtubule acetylation by inhibition of tubulin deacetylation |
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its physiological function in oligodendrocytes could be the reorganization and stabilization of the microtubular ultrastructures in the course of ensheathment of axons |
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regulates microtubule (MT) dynamics via promoting MT polymerization and inhibiting histone deacetylase 6 (HDAC6) activity to increase MT acetylation |
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TPPP inhibits cell proliferation by delaying the G1/S-phase and the mitosis to G1-phase transitions |
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plays a crucial role in the differentiation of the zinc-rich oligodendrocytes, the major constituent of myelin sheath |
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microtubule-associated protein, detected in protein inclusions associated with various neurodegenerative disease |
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TPPP and SNCA have two key features: they are disordered and co-enriched/co-localized in brain inclusions |
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TPPP and TPPP3 are intrinsically unstructured proteins (IUPs) that bind and polymerize tubulin and stabilize microtubules, but TPPP2 does not |