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FLASH GENE
Symbol PTRH2 contributors: mct - updated : 17-01-2013
HGNC name peptidyl-tRNA hydrolase 2
HGNC id 24265
DNA
TYPE functioning gene
STRUCTURE 10.19 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2123 - 180 - 2011 21383007
2 - 804 19 179 - 2011 21383007
  • PTRH2 - V2
  • lacking an alternate exon
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Digestiveintestinesmall intestine  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal mitochondria localization sequence
  • a C-terminal UPF0099 domain
  • mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Ptrh2
    Homologene
    FAMILY PTH2 family
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome
    text
  • chromosome, pericentric region
  • mitochondrial protein that is released into the cytoplasm during apoptosis
  • basic FUNCTION
  • promoting caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1
  • aminoacyl-tRNA hydrolase activity
  • mitochondrial protein that induces caspase-independent apoptosis upon its release into the cytoplasm
  • mitochondrial protein that functions as a peptidyl-tRNA hydrolase, but, when released into the cytoplasm, it elicits apoptosis
  • released into the cytosol during anoikis and is uniquely regulated by integrin-mediated attachment
  • effector of anoikis (cell death due to loss of attachment) in suspended cells
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • part of an integrin-specific signaling pathway
  • PTRH2 signaling pathway that acts through ERK regulation
  • a component
  • cytoplasmic PTRH2 forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein, and induces cell death with characteristics of caspase-independent apoptosis
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • negative regulator of Erk and the target of PTRH2 is an Erk phosphatase
  • PTRH2-mediated regulation of BCL-2 was dependent on focal adhesion kinase, PI3K, and AKT1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    conferred cancer cells with enhanced anoikis resistance, adhesive and migratory properties in vitro and specifically potentiated tumor metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    therapeutic importance of restoring PTRH2 expression in cancer cells to circumvent metastasis at least in part through inhibition of the Erk pathway
    ANIMAL & CELL MODELS