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FLASH GENE
Symbol ARMC8 contributors: npt/mct - updated : 11-02-2010
HGNC name armadillo repeat containing 8
HGNC id 24999
DNA
TYPE functioning gene
SPECIAL FEATURE overlapping, opposite orientation
text overlapping TXNDC6 gene
STRUCTURE 110.07 kb     23 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3178 42 385 lung, aorta Kobayashi (2007)
23 - 3832 - 659 uterus Kobayashi (2007)
13 - 3232 42 385 lung, aorta Kobayashi (2007)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus LOC315949
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • may be involved in cell adhesion and mitotic chromosome condensation
  • key component of the CTLH (C-terminal to lissencephaly type-1-like homology motif) complex in mammalian cells (Suzuki 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • components of the CTLH complex (Kobayashi 2007)
  • form complexes in cells with MAEA, RANBP9, MKLN1, RMND5A (Kobayashi 2007)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein association between alpha-catenin and ARMC8 in the cells (associates with alpha-catenin and up-regulates its degradation) (Suzuki 2008)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS