basic FUNCTION
| implicated in ubiquitination through Cullin E3 ligases |
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may participate as an adaptor and/or chaperone in the ubiquitin-proteasome protein-degradation pathway |
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constitutes a CUL3-based E3 and the disease-causing mutation inhibits ligase activity in a dominant negative manner, which may lead to the inappropriate accumulation of the substrates targeted for proteasomal degradation |
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is a novel substrate recognition subunit of a CUL3-based Ub ligase complex |
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involved in the ubiquitination of target proteins for proteasome-mediated degradation |