basic FUNCTION
| ATM/ATR checkpoint kinase substrate, displaying robust Holliday junction resolvase activity in addition to 5 prime flap endonuclease activity |
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important for the cells ability to respond to DNA |
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interstrand crosslinks and protein-DNA adducts |
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acts as a docking platform for multiple structure-specific endonucleases |
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with GIYD1 have important functions in the maintenance of genome integrity and in the tolerance to DNA damage inflicted by an alkylating agent |
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scaffold for DNA repair nucleases ERCC4-ERCC1, MUS81-EME1, and GIYD1 |
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regulator of structure-specific nucleases and with GIYD1 are important regulators of genome stability in human cells |
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assembles a modular toolkit for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure |
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coordinates three separate endonucleases, and recently recognized as an important regulator of DNA repair |
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mediate repair during replication and can also resolve Holliday junctions formed during homologous recombination |
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requirement to interact with the structure-specific endonuclease ERCC4-ERCC1 to promote crosslink repair |
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play an essential role in cell proliferation, probably by promoting the resolution of interchromatid homologous recombination intermediates |
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plays a key role in the repair of spontaneous DNA damage |
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plays a key role as an interacting platform for enzymes involved in the processing of HR intermediates and is also linked to the repair of interstrand cross-link, a process coordinated by the FA pathway |
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functions throughout gametogenesis to maintain genome stability, possibly by co-ordinating repair processes and/or by linking DNA repair events to the cell cycle via ATM |
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has a crucial role in preventing excessive RAD9A-dependent activation of CHEK2 (23160493) |
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MUS81-SLX4 activation during mitosis promotes targeted resolution of persistent replication intermediates, which safeguards chromosome segregation |