basic FUNCTION
| directly transfering the ubiquitin to targeted substrates |
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HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells |
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involved in the conjugation of ISG15 to cellular proteins (Wong 2006) |
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functions as a general E3 ligase for protein ISGylation (Takeuchi 2006) |
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involved in protein modification, ubiquitin cycle |
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plays an important role in ubiquitination of NME2 (Hochrainer 2008) |
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catalyzes the conjugation of ubiquitin-like protein ISG15 onto IRF3 (Shi 2010) |
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positive regulator of innate antiviral responses that sustains IRF3 activation via a novel posttranslational modification, ISGylation (Shi 2010) |
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markedly induced by type I IFNs and functions as an ISG15 E3 ligase to promote ISGylation (Shi 2010) |
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positive regulator of antiviral innate immune responses, which maintains IRF3 stability via catalyzing ISGylation of IRF3 (Shi 2010) |