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FLASH GENE
Symbol HERC5 contributors: mct - updated : 03-09-2010
HGNC name hect domain and RLD 5
HGNC id 24368
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text clustered with HERC3 and HERC6
STRUCTURE 49.05 kb     23 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 3525 11.67 1024 - Hochrainer (2005)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinethyroid    
Lymphoid/Immunethymus    
Nervousbrainhindbrainmedulla oblongata  
Reproductivefemale systemovary   
 male systemtestis  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text highly in fetal brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one HECT-type E3 ubiquitin-protein ligase domain
  • five RCC1 repeats, RCC1-like domains (RLD)
  • HOMOLOGY
    Homologene
    FAMILY
  • HERC family
  • CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • directly transfering the ubiquitin to targeted substrates
  • HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells
  • involved in the conjugation of ISG15 to cellular proteins (Wong 2006)
  • functions as a general E3 ligase for protein ISGylation (Takeuchi 2006)
  • involved in protein modification, ubiquitin cycle
  • plays an important role in ubiquitination of NME2 (Hochrainer 2008)
  • catalyzes the conjugation of ubiquitin-like protein ISG15 onto IRF3 (Shi 2010)
  • positive regulator of innate antiviral responses that sustains IRF3 activation via a novel posttranslational modification, ISGylation (Shi 2010)
  • markedly induced by type I IFNs and functions as an ISG15 E3 ligase to promote ISGylation (Shi 2010)
  • positive regulator of antiviral innate immune responses, which maintains IRF3 stability via catalyzing ISGylation of IRF3 (Shi 2010)
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds UBQLN1 and UBQLN2
  • binds to CCNA1, CCNB1, CCND1 and CCNE1
  • interaction of HERC5 with the metastasis suppressor NME2 (Hochrainer 2008)
  • specific binding protein of IRF3 (Shi 2010)
  • cell & other
    REGULATION
    activated by in endothelial cells by the pro-inflammatory cytokines tumor necrosis factor alpha and interleukin 1beta, and by lipopolysaccharide (LPS)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS