basic FUNCTION
| having an ubiquitin-protein ligase activity |
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regulates cellular pathways that contribute to anchorage-independent growth and cellular transformation (Huh 2005) |
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plays an important role in mammalian development, such as angiogenesis in the yolk sac (YS), in part through regulation of bulk degradation by lysosomal hydrolases |
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dual function of UBR4 in selective proteolysis by the proteasome and bulk degradation by the lysosome |
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plays likely a dual role in selective degradation of short-lived proteins via the proteasome and bulk degradation of cellular materials via the lysosome |
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counteracts likely specific Ca(2+)-induced death pathways through regulation of Ca(2+) homeostasis and signaling |
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regulates spindle orientation in apical neural progenitors and contributes to neurogenesis in the developing neocortex |
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multifunctional protein with roles in anoikis, viral transformation and protein degradation |