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FLASH GENE
Symbol VEGFC contributors: mct - updated : 22-01-2015
HGNC name vascular endothelial growth factor C
HGNC id 12682
DNA
TYPE functioning gene
STRUCTURE 109.20 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2076 46.75 419 - 1997 9312130
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinesmall intestine  highly
Endocrinepancreas   moderately
 thyroid   highly
Reproductivefemale systemovary  highly
 female systemplacenta  highly
Respiratorylung   moderately
 respiratory tracttrachea  lowly
Skin/Tegumentskin   highly
Urinarybladder   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  moderately
Connective   moderately
Muscularstriatumcardiac  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five cysteine-rich motifs
  • a platelet-derived growth factor (PDGF) domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Vegfc (85.54 pc)
    homolog to murine Vegfc (86.27 pc)
    Homologene
    FAMILY
  • PDGF/VEGF growth factor family
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • involved in vasculogenesis
  • active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels
  • stimulating RANKL-mediated bone resorption
  • may have a role in the progressive growth and invasion of gallbladder cancer through an autocrine mechanism (
  • regulatory role of VEGFC in initiating and potentiating neo-angiogenesis, and does promote angiogenesis via RHOA mediated pathway
  • is a neurotrophic factor that influences the dopaminergic system through multiple mechanisms
  • macrophage-derived VEGFC activates FLT4 in tip cells to reinforce NOTCH signalling, which contributes to the phenotypic conversion of endothelial cells at fusion points of vessel sprouts
  • potential role of VEGFC in the pathogenesis and development of a conjonctival pterygium through lymphangiogenesis
  • FAS and NFKB play a role in the initiation and development of breast cancer, while VEGFC appears to promote lymph node metastasis
  • important for angiogenesis in endometriosis
  • FLT4 with its cognate ligand vascular endothelial growth factor C (VEGFC), is a major mediator of lymphangiogenesis
  • acts primarily on endothelial cells, but also on non-vascular targets, for example in the CNS and immune system
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS cardiovascular , angiogenesis
    PATHWAY
    metabolism
    signaling signal transduction
  • VEGFC/FLT4 signaling pathway is essential for lymphangiogenesis (the formation of lymphatic vessels from pre-existing vasculature) during embryonic development, tissue regeneration and tumor progression
  • a component
  • RSPO1-WNT-VEGFC-FLT4 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • high affinity for both KDR (VEGFR2) and FLTR (VEGFR3)
  • ligand of FLT4
  • NRP2 is a transmembrane receptor for the lymphangiogenic vascular endothelial growth factor C (VEGFC), plays an important role in lymphatic vessel sprouting
  • interaction between NRP2 and FLT4 mediates proper lymphatic vessel sprouting in response to VEGFC
  • CYR61 modulates the VEGFC expression of decidual natural killer cells via PI3K/AKT pathway
  • EDN1 is potent lymphangiogenic factor that relies on the interplay with hypoxic microenvironment and with VEGFA, VEGFC, and FIGF (PMID;
  • VEGFC and FIGF play a role in the induction of osteoclast differentiation through both KDR and FLT4 receptors (
  • VEGFC and its receptor FLT4 mediate lymphangiogenesis
  • in the tumor microenvironment, the reciprocal interplay between FGF2 and VEGFC collaboratively stimulated tumor growth, angiogenesis
  • PTGS2 and and VEGFC are inducers of lymphangiogenesis and their expression levels were correlated in non-Hodgkin lymphoma
  • CAPN2 may contribute to the promoter methylation of DPYSL3 to repress its transcription, leading to the metastasis of Prostate carcinoma via enhancing VEGFC expression
  • cathepsin D is a protease that can activate VEGFC as well as FIGF
  • cell & other
    REGULATION
    activated by KLK3 (KLK3 activated VEGFC specifically and efficiently through cleavage at a novel N-terminal site)
    induced by hypoxia-inducible
    TGFB1
    repressed by downregulated by VHL
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in vascular invasion, involving lymphatic vessels and lymph node, distant metastasis and poor clinical outcomes
    constitutional     --over  
    in eutopic and ectopic endometrium of endometriosis patients
    tumoral     --low  
    in lung and colon cancer cells decelerates tumor growth and inhibits metastasis via multiple mechanisms
    tumoral     --over  
    of VEGFC and FIGF correlates with lymph node metastasis and poor prognosis in patients with resected esophageal cancer (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    high potentiality of VEGFC as a cancer drug target
    ANIMAL & CELL MODELS