basic FUNCTION
| involved in vasculogenesis |
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active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels |
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stimulating RANKL-mediated bone resorption |
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may have a role in the progressive growth and invasion of gallbladder cancer through an autocrine mechanism ( |
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regulatory role of VEGFC in initiating and potentiating neo-angiogenesis, and does promote angiogenesis via RHOA mediated pathway |
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is a neurotrophic factor that influences the dopaminergic system through multiple mechanisms |
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macrophage-derived VEGFC activates FLT4 in tip cells to reinforce NOTCH signalling, which contributes to the phenotypic conversion of endothelial cells at fusion points of vessel sprouts |
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potential role of VEGFC in the pathogenesis and development of a conjonctival pterygium through lymphangiogenesis |
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FAS and NFKB play a role in the initiation and development of breast cancer, while VEGFC appears to promote lymph node metastasis |
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important for angiogenesis in endometriosis |
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FLT4 with its cognate ligand vascular endothelial growth factor C (VEGFC), is a major mediator of lymphangiogenesis |
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acts primarily on endothelial cells, but also on non-vascular targets, for example in the CNS and immune system |