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FLASH GENE
Symbol HSPA13 contributors: mct - updated : 20-08-2015
HGNC name heat shock protein 70kDa family, member 13
HGNC id 11375
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 12.07 kb     5 Exon(s)
regulatory sequence Binding site
MAPPING cloned Y linked   status confirmed
Map cen - D21Z1 - STCH - D21S516 - D21S236 - D21S13 - D21S192 - D21S172 - D21S4 - D21S110 - D21S59 - D21S225 - D21S11 - D21S52 - D21S1 - D21S95 - D21S18 - D21S222 - qter
Authors De Sario (97)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 4001 - 471 - 2000 10675567
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal ATPase domain
  • an unique hydrophobic signal sequence
  • without C-terminal DNA binding domain
  • HOMOLOGY
    Homologene
    FAMILY stress 70 chaperone family member
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • involved in the processing of cytosolic and secretory proteins
  • Hsp70-like protein, playing a role in regulating cell cycle and cell death events
  • has likely a role in cell survival via modulation of the TRAIL-mediated cell death pathway
  • novel role of HSPA13 in the regulation of pHi through site-specific interactions with SLC4A4 and SLC9A1 and subsequent modulation of membrane transporter expression
  • may play a role in pHi regulation at times of cellular stress by enhancing the recovery from intracellular acidification
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is interacting with SLC4A4 at the N-terminal (amino acids 96-440) region
  • site-specific interactions of HSPA13 with SLC4A4 and SLC9A1 and subsequent modulation of membrane transporter expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility susceptibility to gastric cancer
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    corresponding disease(s)
    Susceptibility to gastric cancer
    Variant & Polymorphism SNP increasing the risk of gastric cancer
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS