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FLASH GENE
Symbol PLEKHA6 contributors: mct - updated : 19-09-2018
HGNC name pleckstrin homology domain containing, family A member 6
HGNC id 17053
DNA
TYPE functioning gene
STRUCTURE 159.53 kb     20 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 7434 - 1048 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   moderately
Endocrinepancreas   moderately
Nervousbrainbasal nucleicorpus callosum moderately
Reproductivefemale systemovary  moderately
 male systemtestis  moderately
Respiratorylung   lowly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver, brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a PH domain
secondary structure
  • PH domain consists of a seven-stranded-beta-sandwich, which forms a pair of perpendicular beta-sheets capped by a C-terminal amphipathic alpha-helix
  • HOMOLOGY
    interspecies homolog to murine Plekha6
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • might be involved in the pathogenesis of schizophrenia and therapy response )
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    binding to phosphatidyl-inositol-4-phosphate
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS