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FLASH GENE
Symbol MED19 contributors: mct - updated : 11-04-2012
HGNC name mediator of RNA polymerase II transcription, subunit 19 homolog (yeast)
HGNC id 29600
DNA
TYPE anonymous DNA segment
STRUCTURE 8.49 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1605 - 194 - Sato (2004)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunetonsils   highly
Nervousbrainhindbrainmedulla oblongata  
Urinarykidneytubuleconvoluted tubuleproximal tubule 
Visualeyelens   
 eyeanterior segmentiris  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Connectivebone  highly
Connectivebone  highly
Epithelialsensoryolfactory  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • multiprotein coactivator required for activation of RNA polymerase II transcription by DNA binding transactivators
  • novel proliferation regulator that promotes growth of lung cancer cells
  • plays a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas
  • serves as a novel proliferation regulator that promotes growth of prostate cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MED19 and MED26 subunits in Mediator are direct physical and synergistic functional targets of REST
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    may serve as a new molecular target for lung cancer therapy
    ANIMAL & CELL MODELS