Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NANOS3 contributors: mct/npt/pgu - updated : 01-06-2016
HGNC name nanos homolog 3 (Drosophila)
HGNC id 22048
DNA
TYPE functioning gene
STRUCTURE 3.62 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 946 - 192 - 2003 12947200
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary  highly Homo sapiens
 male systemtestis  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
Reproductiveoocyte Homo sapiens
Reproductivespermatogonia Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text
  • expressed in both male and female gonads of early embryo and, after birth, it is found only in the testis
  • enriched in the fetal ovary, testis and brain
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a zinc finger motif
  • HOMOLOGY
    Homologene
    FAMILY
  • nanos gene family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text
  • highest in germ cell nuclei where the protein co-localized with chromosomal DNA during mitosis/meiosis
  • basic FUNCTION
  • having a conserved function in germ cell development
  • is able to delay the cell cycle progression of spermatogonial cells
  • in the prepuberal testis, is important to maintain undifferentiated spermatogonia via the regulation of their cell cycle
  • essential protein required for the germ cell maintenance
  • with TIAL1 would play critical functions in posttranscriptional regulations in primordial germ cells soon after their specification
  • functions in human germ cell development
  • modulates essential aspects of human germ cell development perhaps during the cell cycle
  • NANOS1 is involved in the G1/S and NANOS3 in the G2/M phase transition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    TIAL1 would play critical functions
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    significantly alter the germ cell number and expression patterns of genes that regulate important germ cell properties, including maintenance of pluripotency, germ cell development and meiotic progression
    constitutional germinal mutation      
    in Primary ovarian insufficiency (POI)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS