basic FUNCTION
| potential intervention at the capping checkpoint step of the transcription cycle |
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transcription elongation factor, C-terminal domain (CTD) phosphatase with specificity for serine-5-P |
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role for its C-terminal domain phosphatase in RNA polymerase II transcription elongation |
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having a dual role in transcription, one as a CTD S5-P phosphatase that regenerates the initiation-competent, hypophosphorylated form of RNAP II and the other as a factor necessary for cleavage of pre-mRNA and efficient transcription termination |
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having a role in transcription-coupled pre-mRNA 3prime-end processing |
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regulates the cohesion of chromosome arms but not centromeres, and acts by counteracting the phosphorylation of STAG2 |
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cohesin-binding protein capable of regulating cohesion between sister chromatid arms |
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potentially involved in sister chromatid arm cohesion as early as the G2 phase of the cell cycle |
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regulates cohesion at the chromosome arms in a WAPAL-independent manner |
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essential phosphatase conserved in eukaryotes that dephosphorylates phosphorylated Ser5 of the CTD heptapeptide |
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its function is implicated in transcription initiation, elongation and termination, as well as RNA processing |