protein
| TIM21, a specific subunit of the sorting-active presequence translocase, recruits proton-pumping respiratory-chain complexes and stimulates preprotein insertion |
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TIMM21 could shuttle between TIMM23 and MITRAC complexes to fulfill a more direct function in the assembly process of nuclear-encoded subunits into assembly intermediates |
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C-terminal sequence of TIMM23 is dispensable for growth and functions as an inhibitor for binding of TIMM21 |
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while ROMO1 is dispensable for general protein import along the presequence pathway, it participates in the dynamics of TIMM21 during respiratory chain biogenesis and is specifically required for import of YME1L |