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FLASH GENE
Symbol TIMM21 contributors: mct - updated : 22-05-2019
HGNC name translocase of inner mitochondrial membrane 21
HGNC id 25010
DNA
TYPE functioning gene
STRUCTURE 10.46 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1562 - 248 - 2012 23260140
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Nervousbrain    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticplasma   
Epithelialbarrier liningendometrium  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION
  • is dispensable for protein import but required for integration of early-assembling, presequence-containing subunits into respiratory-chain intermediates
  • in mitochondria, TIMM21 shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes
  • does not associate with mature cytochrome c oxidase complexes but rather represents a constituent of assembly intermediates
  • TIMM21 is the first assembly factor that is involved in the transfer of newly imported proteins from the presequence translocase to assembling respiratory-chain complexes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the inner-membrane presequence translocase, and is also present in the major assembly intermediates containing newly mitochondria-synthesized and imported respiratory-chain subunits, the MITRAC complexes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TIM21, a specific subunit of the sorting-active presequence translocase, recruits proton-pumping respiratory-chain complexes and stimulates preprotein insertion
  • TIMM21 could shuttle between TIMM23 and MITRAC complexes to fulfill a more direct function in the assembly process of nuclear-encoded subunits into assembly intermediates
  • C-terminal sequence of TIMM23 is dispensable for growth and functions as an inhibitor for binding of TIMM21
  • while ROMO1 is dispensable for general protein import along the presequence pathway, it participates in the dynamics of TIMM21 during respiratory chain biogenesis and is specifically required for import of YME1L
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS