basic FUNCTION
| playing a major role in the formation, packaging, processing, and function of mRNA |
|
playing a role in in transcriptional regulation |
|
PTBP1 and HNRNPL are positive regulators of SLC7A1 mRNA translation via the internal ribosome entry site (IRES) under stress conditions that cause a global decrease of protein synthesis |
|
PTBP1 and an HNRNPL, promote the efficient translation of SLC7A1 mRNA during amino acid starvation |
|
can regulate alternative mRNA splicing in diverse ways, binding to exonic or intronic sites and acting as either an activator or repressor |
|
is a key factor involved in the spermatogenesis |
|
HNRNPL regulates T cell differentiation and migration by regulating pre-TCR and chemokine receptor signaling |
|
HNRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition |
|
HNRNPLL and HNRNPL have overlapping, but distinct, expression patterns and functional consequences |
|
HNRNPLL has a greater silencing activity than HNRNPL |
|
HNRNPL and HNRNPLL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA |
|
a multifunctional RNA-binding protein that is involved in many different processes, such as regulation of transcription, translation, and RNA stability |
|
HNRNPL is a new regulator for CD44 V10 exon splicing |