Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ABCE1 contributors: mct - updated : 17-01-2017
HGNC name ATP-binding cassette, sub-family E (OABP), member 1
HGNC id 69
DNA
TYPE functioning gene
STRUCTURE 31.52 kb     18 Exon(s)    one Copie(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
INPP4B 4q31.11 inositol polyphosphate-4-phosphatase, type II, 105kDa USP38 4q31.1 ubiquitin specific protease 38 GAB1 4q31.4-q13.5 GRB2-associated binding protein 1 SMARCA5 4q31.1-q31.2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 LOC389229 4 similar to Beta-glucuronidase precursor (Beta-G1) LOC166752 4q31.1 similar to embryonic blastocoelar extracellular matrix protein precursor GYPE 4q31 glycophorin E LOC152891 4q31.1 similar to WW45 protein GYPB 4q28-q31 glycophorin B (includes Ss blood group) GYPA 4q28.2-31.1 glycophorin A (includes MN blood group) LOC391703 4 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) HHIP 4q28-q32 hedgehog interacting protein LOC345041 4q31.21 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) APC10 4q31 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) ABCE1 4q31 ATP-binding cassette, sub-family E (OABP), member 1 HSHIN1 4q31.21 HIV-1 induced protein HIN-1 LOC389230 4 LOC389230 LOC152905 4q31.21 similar to Reticulon protein 3 (Neuroendocrine-specific protein-like 2) (NSP-like protein II) (NSPLII) FLJ13262 4q31.21 hypothetical protein FLJ13262 MADH1 4q28 MAD, mothers against decapentaplegic homolog 1 (Drosophila) DKFZP586M0622 LOC345045 4q31.21 similar to nuclear receptor coactivator 4; RET-activating gene ELE1 MMAA LOC152485 4q31.21 hypothetical protein LOC152485 LSM6 4q31.21 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) LOC345051 4q31.21 similar to MGC53273 protein DKFZP566M114 4q31.21 hypothetical protein DKFZp566M114 POU4F2 4q31.2 POU domain, class 4, transcription factor 2 NYD-SP14 4q31.21 NYD-SP14 protein EDNRA 4q31.21 endothelin receptor type A GTF2F2L 4q31 general transcription factor IIF, polypeptide 2-like FLJ10846 4q31.22 hypothetical protein FLJ10846 LOC90826 4q31.22 hypothetical protein BC004337 FLJ20896 4q31.22 hypothetical protein FLJ20896 NR3C2 4q31 nuclear receptor subfamily 3, group C, member 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 4194 - 599 - 2007 17355973
18 - 4191 - 599 - 2007 17355973
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Digestivepharynx   highly
 salivary gland   highly
Reproductivefemale systemovary   
 male systemtestis   
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a unique N-terminal region with eight conserved cysteines, predicted to coordinate iron-sulfur clusters (N-terminal Fe-S binding domain)
  • eight cysteine, histidine and lysine residues
  • twin ABC ATPase domains, which are arranged in a head-to-tail orientation via a flexible linker and hinge region
  • two essential diamagnetic [4Fe-4S]2+ clusters
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Abce1
    Homologene
    FAMILY ATP binding cassette superfamily, subfamily E (OABP)
    CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • playing a critical role for proper assembly of the HIV-1 capsid
  • playing a role in RNase L inhibition, human immunodeficiency virus (HIV1)capsid maturation, translation initiation, and ribosome biosynthesis
  • role in eukaryotic translation has been linked to several stages during protein synthesis, including initiation and most recently termination and ribosome recycling
  • required for the assembly of the HIV and SIV gag polypeptides
  • promotes eukaryotic ribosomal recycling over a wide range of Mg(2+) concentrations
  • play an important role in the pathogenesis of human small cell lung cancer cell
  • essential and highly conserved protein that requires notoriously ROS-labile cofactors (Fe-S clusters) for its functions in protein synthesis
  • its function is a primary target of ROS action
  • is closely connected with the pathogenesis and development of esophageal carcinoma, which act through the cellular pathways of RNASEL
  • ribosome-recycling factor important for translation termination in mammalian cells
  • is crucial for ribosome recycling and controls ribosome homeostasis
  • is involved in histone biosynthesis and DNA replication and therefore is essential for normal S phase progression
  • erythroid cells and platelets ribosomes accumulate as a result of the natural loss of the ribosome recycling factor ABCE1 during terminal differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    Rnase4 inhibitor, 2', 5'-oligoisoadenylate dependent, interferon regulated pathway
    a component
  • ABCE1/Pelota/HBS1L also dissociated vacant 80S ribosomes, which stimulated 48S complex formation, suggesting that Pelota/HBS1L have an additional role outside of stable secondary structures (NGD)
  • heterodimer with RNASEL, ABCE1 protein inhibits the IFN-depended RNASEL system and regulates a broad range of biological functions including viral infection, tumor cell proliferation, and antiapoptosis
  • INTERACTION
    DNA
    RNA
    small molecule playing a role in RNase L inhibition, human immunodeficiency virus (HIV) capsid maturation, translation initiation, and ribosome biosynthesis
    protein
  • interact with translation initiation factors, eIF2, eIF3, eIF5, the 40 S ribosomal subunit, and several ribosomal RNAs
  • UBASH3A bind to ABCE1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion
  • interacting with PELO/HBS1L (Pelota/HBS1L induced dissociation of elongation complexes and release of peptidyl-tRNA, but only in the presence of ABCE1)
  • RNASEL inhibitor, ABCE1 is currently recognized as an essential translation factor involved in several stages of eukaryotic translation and ribosome biogenesis
  • ABCE1 interacts with the cytoskeleton protein actin and increases cell motility
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    is correlated with aggressive growth and metastasis in lung cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    may be used as a potential target of gene therapy for small cell lung cancer
    ANIMAL & CELL MODELS