protein
| YTHDF2 recruits the CCR4-NOT complex through a direct interaction between the YTHDF2 N-terminal region and the SH domain of the CNOT1 subunit, and this recruitment is essential for the deadenylation of m(6)A-containing RNAs by CAF1 and CCR4 |
|
FMR1 regulates the stability of its m6A-marked mRNA targets through YTHDF2, which could potentially contribute to the molecular pathogenesis of Fragile X syndrome (FXS) |
|
YTHDF2 depletion increased the expression and stability of MAP2K4 and MAP4K4 mRNAs |
|
YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators (CUL4A, DDB1, CUL1, SKP2) |