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FLASH GENE
Symbol MGAT4C contributors: mct - updated : 20-02-2013
HGNC name mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
HGNC id 30871
DNA
TYPE functioning gene
STRUCTURE 860.00 kb     14 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2565 56 478 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrainforebraincerebral lobefrontal lobe 
 braindiencephalonhypothalamus  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a highly hydrophobic N-terminal region, which may be a transmembrane domain
  • a hydrophilic region, which may be a stem region
  • lacking the proline-rich stem sequence found in other N-acetylglucosaminyltransferases
  • HOMOLOGY
    Homologene
    FAMILY
  • glycosyltransferase 54 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • glycosyltransferase involved in catalyzing GlcNAc beta1–4 linkage to the core mannose residues of N-glycans for tri- or tetraantennary N-glycan structures
  • predicted glycosyltransferase, implicated in PROM1 N-glycosylation
  • may have potentially an important role in certain cancers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • positive regulator of cell surface PROM1 expression
  • PROM1 acts as an MGAT4C substrate for complex N-glycan processing, which contributes to cell surface PROM1 recognition
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS