basic FUNCTION
| acting within the secretory pathway to catalyze N-terminal palmitoylation of 'hedgehog' |
|
in the developing testis, HHAT is not required for Sertoli cell commitment but plays a role in proper testis cord formation and the differentiation of fetal Leydig cells |
|
is the enzyme in the endoplasmic reticulum that palmitoylates Hedgehog proteins, is a member of a small subfamily of membrane-bound O-acyltransferase proteins that acylate secreted proteins, and is an important drug target in cancer |
|
HHAT regulated the proliferation of both SHH responsive and non-responsive ESR1 positive cells, suggesting a SHH independent function for HHAT |